Day Two - Thursday, August 1, 2024
7:45 am Check In & Coffee
8:25 am Chair’s Opening Remarks
Unveiling the Intersection of Aging Biology & Heart Failure: A Spotlight on Developments & Relevance
8:30 am Tackling Age-Related Changes That Can Create a Permissive Environment for Heart Disease
Synopsis
- Discussing age-related gene expression signature in heart and other organs
- Assessing age-related changes in Activin signalling
- Exploring the effect of Activin on the heart
9:00 am Using Proteomics to Target Aging Biology in Heart Failure
Synopsis
- Understanding the relevance of aging biology in heart failure pathophysiology
- Investigating distinct protein signatures of aging associated with heart failure
- Approaches to targeting aging biology for therapeutic development in heart failure
Innovations in Cardiovascular Precision Medicine
9:30 am Delving to Non-Coding RNA Pathways as a New Frontier in Addressing Cardiac Diseases
Synopsis
- Understanding the regulatory importance of ncRNAs for cardiac cellular processes
- Engaging non-coding RNA pathway manipulation to reverse cellular pathology and restore normal function in cardiomyocytes
- Overcoming cardiac hypertrophy, fibrosis, impaired contractility and reduced vascularisation through an oligonucleotide-based inhibitor
10:00 am Morning Break & Networking
10:45 am Reconceptualizing Gene Pathways in Heart Failure
Synopsis
- Exploring associations with signalling pathways and heart failure to accelerate early diagnosis
- Highlight progress in understanding of genetic architecture of heart failure
- Evaluating current capacities to deep mine existing knowledge to predict responses
11:15 am Probing How Cell Therapy can be Utilized in Heart Failure
Synopsis
- Delving into cell therapy using purified cardiomyocytes
- Exploring cardiac muscle regeneration through cell therapy
- Investigating categories of heart failure patients this would be applicable to
11:45 am Panel Discussion: Exploring Recent Innovations with Precision Medicine
Synopsis
- How can the capabilities of gene and cell therapy be synergistically applied in cardiovascular research
- Reviewing the integration of precision medicine strategies in preclinical research
- From gene therapy to cell therapy to non-coding RNA which of these therapies hold the most promise
12:15 pm Lunch & Networking
Showcasing Novel Approaches with Small Molecules to Improve Contractility
1:45 pm Harnessing Small Molecules to Regulate Sarcomere Contractility
Synopsis
- Analyzing cardiac myosin manipulation
- Overcoming cardiac muscle function, muscle weakness and fatigue
- Evaluating categories of heart failure patients this would be applicable to
2:15 pm Targeting Cardiac Myosin Binding Protein C for Hypertrophic Cardiomyopathy & Heart Failure
Synopsis
- Investigating small molecules potential within heart failure
- Exploring the modulation of cardiac myosin binding protein C to improve cardiac function
- Discussing on going preclinical development
2:45 pm Panel Discussion: Dissecting Novel Biology from GLP-1RAs, to Small Molecules, to New Targets to Advance Progress in the Heart Failure Space
Synopsis
- Exploring the impact of incretins for cardiomyopathies
- Reviewing the potential of small molecules
- Delving into novel biology for cardiomyopathies